After a year of dissolving the U.S. Agency for International Development (USAID), withdrawing from the World Health Organization (WHO), and reducing foreign assistance for health, the Trump administration is finalizing bilateral arrangements that will define the next era of U.S. global health engagement.

These memoranda of understanding (MOU), released under the America First Global Health Strategy, intend to transition the United States away from aid and toward jointly financed health agreements. The 34 countries that have signed MOUs as of August 3 face widely varying cofinancing provisions, raising questions about their capacity to meet spending benchmarks, achieve target health outcomes, and replace foreign assistance.

This interactive assesses the sustainability and scope of the cofinancing obligations under the MOUs. Toward this effort, we analyze the partner governments' recent and projected health spending, examine how U.S. funding is expected to change under the agreements, and evaluate the available text of the MOUs.

We will continue to update the interactive as new MOUs are signed and track developments related to the agreements. Most recently, Think Global Health (TGH) evaluated whether the agreements are likely to facilitate the efficient distribution of the breakthrough HIV drug lenacapavir at the country level.

Overall, global health financing dropped 21% from 2024 to 2025, according to the Institute for Health Metrics and Evaluation (IHME). Further reductions are expected for multilateral organizations. Our analysis suggests that some countries, such as Liberia, could face significant year-over-year drops in U.S. funding for health alongside sharp increases in cofinancing expectations that exceed previous spending projections. Other agreements, such as Mozambique's, more closely reflect the country's spending capacity.

Accompanying press releases signal a shift in U.S. assistance toward health security and away from health areas that received earlier support, including family planning, maternal health, and children's health. Countries could choose to continue funding those areas independently, but they may need to target spending on U.S. priorities to meet cofinancing requirements, adding further strain in arenas where health aid has been cut.

In the table below, TGH is providing hyperlinks to ten full MOU texts, the details of which are described throughout the analysis.

Tracking Global Lenacapavir Access 

On April 14, the State Department announced an expanded partnership with Gilead Sciences and the Global Fund to scale up distribution of lenacapavir, a twice-yearly injectable shown to be nearly 100% effective at preventing HIV. The announcement builds on a 2025 commitment, raising the target from 2 million to 3 million people to be reached by 2028.

The Global Fund is splitting procurement with the President's Emergency Plan for AIDS Relief (PEPFAR) to provide 24 countries access to lenacapavir by the end of 2026. As the Global Fund's top donor and through PEPFAR, the United States will play a significant role in directing which countries will receive these first shipments. According to U.S. Under Secretary for Foreign Assistance Jeremy Lewin, MOU signatories may be better positioned to "develop a plan for lenacapavir at a national scale" because of the countries' "much closer relationship" with the Global Fund and the United States. He also shared that the agreements' cofinancing structure can "get additional doses to the field" to "create a really durable demand."

So far, lenacapavir partnerships announced to date indicate that access is not conditional on successfully signed MOUs. Only half of the 24 countries that are set to receive lenacapavir by the end of 2026 have committed to agreements. Of the nine countries that have received and begun implementing lenacapavir to date, two—Zambia and Zimbabwe—have not endorsed a MOU because of discontinued negotiations. A third—South Africa—was not extended an MOU and may lose U.S. AIDS funding according to a June State Department statement, yet accounts for over half of Africa's lenacapavir users as reported at the 2026 International AIDS Conference.

Only half the available MOU full texts mention plans for lenacapavir partnerships. The mentions appear to have little bearing on shipments to date: despite no reference to the drug in Mozambique's and Nigeria's texts, both countries have already received the drug. Conversely, of the four texts that explicitly reference such partnerships, only two (Kenya and Rwanda) have been extended support from the Global Fund. Roughly 1 in 10 people in Cameroon—whose MOU outlines a lenacapavir partnership but notably has yet to be extended support—die prematurely due to HIV-related causes.   

How Much Do Countries Spend on Health?

Although a handful of MOUs have been signed in Asia, Latin America, and Oceania, the majority reflect partnerships with African countries. African leaders have long promised to grow domestic health spending and systems-wide self-reliance, a sentiment that 46 African Union countries captured in the 2001 Abuja Declaration [PDF] to allocate 15% of their government budgets to health. As of 2024, African governments devote roughly 7% of their national budgets to health, on average.

So far, the 34 MOUs govern spending between 2026 and 2030 and total at least $24.2 billion

Consistent with long-standing domestic financing goals, the new bilateral agreements outline how the United States will transfer funding responsibility from nongovernmental organizations (NGOs) and other implementing partners, previously contracted with USAID, to recipient governments, who agree to increase their investment shares over the duration of the partnerships. So far, the 34 MOUs govern spending between 2026 and 2030 and total at least $24.2 billion, roughly 40% to be funded by the recipient governments over the next three to five years. Nigeria's, Tanzania's, and Kenya's are the largest packages signed to date.

Under the MOUs, some countries face more demanding funding expectations than others. Nigeria and Botswana pledged to fund some of the largest shares of MOU spending, 59% and 78%, respectively. Despite committing to co-invest a substantial $3 billion, Nigeria expects to increase its health spending as a proportion of its national budget only marginally, from 5% [PDF] as proposed in its 2025 budget to at least 6% [PDF] from 2026 to 2030.

Botswana, conversely, already has strong baseline health spending, reaching more than 15% of its government budget in 2023. The memoranda's additional expectations raise concerns that the deal could strain a system already heavily committed to health financing, especially considering economic pressures from their shrinking diamond industry. Botswana's agreement—akin to Bolivia's, Panama's, and South Sudan's—is two years shorter than the others. The condensed timeline means that Botswana will absorb health-system financial responsibility sooner than other African countries, but it also reflects a mutual belief in Botswana's higher economic capacity: the country by far has the highest gross national income (GNI) of any African MOU partner as of August 3.  

Other countries—Bolivia, Burundi, Cambodia, Dominican Republic, Eswatini, Guatemala, Madagascar, Malawi, Mozambique, Papua New Guinea, and South Sudan—have committed to modestly increasing their health expenditures relative to 2025 spending baselines. Each proposes to finance less than a quarter of the MOU packages. Although these co-investment expectations fall short of the America First Global Health Strategy's goal [PDF] to transition most partner countries to full self-reliance through the agreements, they account for country-level fiscal constraints.

Malawi, for example, allocated only 7% of its 2023 budget to health, meaning its lower cofinancing expectation could permit a more gradual and realistic transition to self-reliance. Mozambique, meanwhile, allocated approximately the same share as Malawi—roughly 8% of its national budget—to health, yet it signed a cofinancing commitment five times lower than Malawi's. The smaller cofinancing share could be explained by the country's exceptionally high debt-repayment obligation: in 2025, 97.2% of Mozambique's gross domestic product (GDP) was owed in public debt, the highest of all MOU partner countries.

Not All MOUs Are Created Equal

Nine MOU draft texts—for Cameroon, Ethiopia, Kenya, Liberia, Mozambique, Nigeria, Rwanda, South Sudan, and Uganda—provide details on annual funding commitments that are not available in the U.S. State Department press releases announcing the deals. For each, the cofinancing expectations increase by year relative to a 2025 baseline, with the U.S. contributions decreasing correspondingly. A tenth MOU text—Ivory Coast's—does not include U.S. annual contributions and is not included in the below two charts.

Some countries expecting to increase their total health co-investments—combined domestic and U.S. spending—will experience budget fluctuations each year under the MOUs, which could disrupt program continuity.

Health co-investments from Ethiopia, Nigeria, Rwanda, and Uganda are modestly larger in 2030 than in 2026. But while Nigeria's and Uganda's total health budgets rise steadily before flattening at their tail ends, co-investments in Ethiopia and Rwanda will fluctuate. Ethiopia's health budget will peak in 2028 and drop steadily through 2030, while Rwanda's will more than double from 2026 to 2027, only to decline sharply.

Liberia's co-investment packages are similarly volatile, dropping 35% from 2028 to 2029 before elevating once again in the agreement's final year. Kenya, conversely, expects to see a more substantive rise in its annual investment by the end of the MOU, growing $135 million from its 2026 contribution. The rationale for these annual fluctuations is unclear.

Liberia, Mozambique, and South Sudan, however, expect overall declines in annual health spending—even as both increase their domestic contributions. If the countries follow the MOU terms, Liberia's combined health spending will shrink 6% by 2030, while Mozambique's will drop 17%, and South Sudan's will shrink 4% over its three-year agreement. Reductions in total yearly funds over the agreements' lifetime could limit the countries' abilities to meet health outcomes and security benchmarks unless explicit cost-cutting plans are in place.

Some commitments detailed in the MOUs diverge from country-level spending projections provided by IHME and forecast through indicators such as GDP, debt, development assistance for health, and government health expenditures. These discrepancies have implications for the feasibility of the domestic spending pledges.

Among the nine full texts with available cofinancing information, Cameroon, Liberia, Nigeria, South Sudan, and Uganda stand out as partners facing particularly high cofinancing expectations, as their MOU domestic commitments outpace the health budget growth projected by IHME. If these countries are to achieve their stipulated health-spending growth, they could need to either transfer some funding responsibilities to other donors or reallocate resources from other national priorities. Ethiopia, Kenya, Mozambique, and Rwanda, meanwhile, face cofinancing expectations that are slightly below IHME projected growth, suggesting higher likelihoods of smooth implementation.

Ethiopia's and Rwanda's MOUs break from the seven other texts in their calls for sharp domestic-spending increases concentrated toward the very end of the agreement. Ethiopia is expected to more than triple its domestic spending commitment from 2027 to 2028, after which its spending levels out.

Of the $70.6 million domestic-spending commitment, Rwanda will spend 88% in the final two years. This nonlinear rate of growth could create delayed funding obstacles and have the counterintuitive effect of delaying domestic increases in health spending that were expected to occur in the absence of the MOU. By contrast, Cameroon, Kenya, Liberia, Mozambique, Nigeria, and Uganda plan to raise their co-investment shares in a gradual, linear fashion throughout the lifecycle of the agreements.

Disease Area Funding in the MOUs

Over the last two decades, U.S. foreign assistance for health has had broad priorities in Africa, including HIV/AIDS, tuberculosis (TB), malaria, global health security, family planning, reproductive health, and maternal and child health. Two issues—HIV/AIDS and maternal and child health—remain objectives across the new bilateral agreements according to an analysis by the Kaiser Family Foundation (KFF) of available information, including State Department press releases and the available full texts.

Each of the ten full texts highlight specific HIV health outcome benchmarks to reduce the number of new diagnoses across populations of all ages. However, new studies released ahead of the International AIDS conference on July 21, 2026, by multinational researchers from organizations including AmFAR, Heidelberg University Hospital, and the Clinton Health Access Initiative examining the impacts of recent PEPFAR policy changes on HIV services suggest that progress toward those goals could be stalled, after nearly 2,000 HIV clinics shut down globally and a roughly 15% decline in PEPFAR-supported pediatric HIV treatment from 2024 to 2025.

Press releases for the early bilateral agreements signed before August 3 omit some long-standing health priorities. Malaria, which previously received the second highest proportion of U.S. health assistance and has historically been funded across all African partner countries, was not mentioned once in South Sudan's draft full text, while measles was mentioned four times. South Sudan attributed 5.38% of premature deaths in 2023 to malaria—roughly twice the global average—while measles was responsible for 0.43% of premature deaths.

Both Uganda and Mozambique, in their full MOU texts, have set the ambitious goals of significantly reducing maternal mortality by 2030—Uganda by almost 40% and Mozambique by 50%. Tracking progress toward these thresholds will be prudent given the uncertain future of investments in family planning and reproductive health as well as the recent reinstatement and expansion of the Mexico City Policy. As of August 3, maternal and child health is not listed as a priority in the press releases for 18 agreements.

Despite a U.S. legacy of delivering development assistance to address TB, the disease is not mentioned in the available information for 21 agreements. The ten full texts somewhat reinforce these findings, as the agreements for Rwanda, South Sudan, and Liberia do not reference TB even once, despite outlining implementation plans for other diseases.

Kenya's, Ivory Coast's, and Mozambique's texts mention TB, but neither covers health outcomes nor spending benchmarks. Those omissions could hinder progress and accountability for existing TB programs. The other texts, by contrast, outline both health outcome benchmarks and health strengthening proposals for this disease area.

Securing funding for TB care will be important for Lesotho, Burundi, and South Sudan, where, according to IHME, the infectious disease accounted for 8.2%, 5.8%, and 4.65% of premature deaths in 2023, respectively. The current gap between disease burden and health assistance for noncommunicable disease—which account for more than 30% of premature deaths across the initial group of partner countries—will likely persist under the new agreements, with the funding area receiving no meaningful mentions in the available texts.

As countries move toward implementation, information from the ten full texts indicates that the process may be government-dominated. Notable exceptions from those texts include Uganda's and Nigeria's plans to incorporate faith-based organizations in health-care delivery; Mozambique's to continue to involve nongovernmental organizations (NGOs) in HIV responses; and Cameroon's to extend current implementing partner contracts for a limited period during the transition. Further exceptions revealed in U.S. government presentations at the 2026 International AIDS Conference include Cambodia's plan to extend contracts with implementing partners and community-based organizations; the Dominican Republic's to involve NGOs; and Kenya's to incorporate local technical partners.

South Sudan's draft MOU also mandates the return of the oversight of its National Public Health Laboratory (NPHL)—an agency responsible for implementation of public health services like HIV that was reportedly seized by military authority in March, obstructing the delivery of foreign assistance and leading the U.S. Embassy to order an immediate disengagement—to the Ministry of Health by June 1, 2026. Emerging risks of cross-border Ebola spread from the DRC, which currently is experiencing the fastest growing Ebola outbreak in history, raise the urgency of this mandate to ensure smooth entry of foreign assistance should the disease enter the country. 

Detailed implementation plans for each MOU were expected [PDF] by March 31, 2026.

The remaining transition plans have yet to be made public, and transparency of such activities will enable a thorough evaluation of the feasibility and implications of each newly formed partnership.

Until details are confirmed, uncertainties persist around preparing countries' health systems to distribute and maintain new funding after 2030, particularly for countries whose MOU terms do not lead to full self-reliance.

EDITOR'S NOTE: This tracker was originally published on March 3, 2026. We will update it regularly as new information emerges about the health MOUs.